The new science of weight loss and obesity | Dr. Louis J Aronne

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Obesity is a physiological condition that can be managed with the right education and treatment.

In today’s episode, Dr. Louis J. Aronne, a leading expert in obesity research, sheds light on the science behind weight management and obesity treatment.

Dr. Aronne dives into groundbreaking weight loss medications. He also explores how lifestyle and eating habits affect long-term health and why medications combined with dietary changes can unlock transformative results.

Louis J. Aronne, M.D. is a leading authority on obesity and its treatment. He’s a former president of The Obesity Society, which publishes the peer-reviewed scientific journal Obesity, of which Dr. Aronne is an associate editor. He has also authored more than 60 papers and book chapters on the topic.

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Timecodes:
00:00 Introduction
01:01 Quickfire questions
03:51 What is obesity?
05:06 What’s the difference between being overweight and obesity?
07:38 Why has there been such a quick rise in obesity?
10:55 Why it’s not just a lack of willpower
13:50 The complexity of weight regulation
15:54 What is Leptin and why is it so important for weight control?
19:51 The brain’s role in weight regulation
20:36 Curing obesity in animal studies
22:29 Did hunter-gatherers gain weight?
23:58 Natural experiments in weight gain and loss
26:01 Can medications cause weight gain?
28:42 The impact of calorie restriction diets
30:13 Reducing diabetes risk through weight loss
34:10 Research into medications as a tool for weight loss
38:36 How well do weight loss drugs work?
41:38 The future of weight loss drugs
43:51 Will you regain the weight if you stop taking weight loss drugs?
48:08 Can obesity be avoided without the use of drugs?
49:42 Concerns about weight loss drugs

📚 Books from our ZOE Scientists:
– Food For Life by Prof. Tim Spector: https://amzn.to/455DqMz
– Fibre Fuelled by Dr Will Bulsiewicz: https://amzn.to/4bzmUXP
– Every Body Should Know This by Dr Federica Amati: https://amzn.to/4blJsLg

Mentioned in today’s episode:
Persistent metabolic adaptation 6 years after “The Biggest Loser” competition, published in Obesity. Link: https://onlinelibrary.wiley.com/doi/10.1002/oby.21538

The Finnish diabetes prevention study (DPS), published in Diabetes Care
Link: https://diabetesjournals.org/care/article/26/12/3230/21849/The-Finnish-Diabetes-Prevention-Study-DPS

National Diabetes Prevention Program (DPP), from National Institute of Diabetes and Digestive and Kidney Disease
https://www.cdc.gov/diabetes/prevention/index.html

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Episode transcripts are available: https://zoe.com/learn/category/podcasts

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